Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS.

ABSTRACT: Tremor is a well-recognized sign of Parkinson's disease (PD), yet its long-term evolution remains unclear, particularly regarding the relationship between resting and action tremor. This retrospective study examined resting and action tremor using specific UPDRS-III subitems in 301 PD patients treated with bilateral subthalamic nucleus deep brain stimulation (STN-DBS), assessed preoperatively and at one-year follow-up, with 108 and 57 patients re-evaluated at ten and 15 years, respectively. Most patients (61.8%) had both tremor types, with smaller subsets showing isolated resting (14.3%), action (10.6%), or no tremor (13.3%). Resting tremor responded better to L-Dopa, STN-DBS, and their combination than action tremor (p < 0.05) and remained stable long-term. In contrast, action tremor wors

SUBMITTER: Zampogna A 

PROVIDER: S-EPMC12491427 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature