DNAJC5 promotes cisplatin resistance in epithelial ovarian cancer by autophagy induced by the BiP/IRE1α/XBP1 endoplasmic reticulum stress pathway.

ABSTRACT: Ovarian cancer is the most lethal gynecological malignancy, with platinum-based chemotherapy serving as the standard first-line treatment. However, the emergence of primary or acquired resistance significantly compromises patient survival. Among the mechanisms contributing to chemotherapy resistance, autophagy plays a crucial role. DnaJ heat shock protein family (Hsp40) member C5 (DNAJC5) is a key regulator of nervous system function. Recent studies suggest that DNAJC5 may also be involved in tumor progression. Based on this, we aimed to investigate the role of DNAJC5 in epithelial ovarian cancer (EOC) chemotherapy resistance. Survival analysis of the TCGA database revealed a strong association between elevated DNAJC5 expression and poor prognosis in ovarian cancer patients. Immunohistoche

SUBMITTER: Huang S 

PROVIDER: S-EPMC12491438 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature