Systematic review and meta-analysis of antioxidants with or without exercise training improving muscle condition in older adults.

ABSTRACT: Oxidative stress and physical inactivity are regarded as important mechanisms contributing to muscle loss. However, the efficacy of antioxidants and their potential synergy with exercise training remain controversial for older population. The study aimed to evaluate the effects of antioxidants, either combined with or without exercise, on improving muscle strength, mass, and physical performance in older adults. We conducted a comprehensive search of the PubMed, MEDLINE, and Embase databases to identify randomized controlled trials (RCTs) on muscle condition in subjects aged 55 years or older. The search period covered from the inception of each database until June 10, 2024. A total of 39 RCTs involving 1714 participants were included. The meta-analysis presented that antioxidants alone co

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12491480 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature