Curcumin's dual effect on pyroptosis and autophagy in metabolic- associated fatty liver disease: a potential therapeutic strategy.

ABSTRACT: Metabolic-associated fatty liver disease (MAFLD) has become a considerable public health concern due to its elevated prevalence and its probability of progressing into hepatocellular carcinoma. Autophagy and pyroptosis are key cellular processes involved in MAFLD progression, with autophagy acting as a protective mechanism by inhibiting inflammasome activation. At the same time, excessive pyroptosis contributes to inflammation and tissue damage. Gasdermin D (GSDMD), a key executor of pyroptosis, plays a central role in this process by mediating inflammatory cell death and has emerged as a potential marker of liver injury severity. This study evaluates curcumin's effects on liver fat accumulation, inflammatory cytokine levels, oxidative stress, and its potential to regulate autophagy and py

SUBMITTER: Eldken ZH 

PROVIDER: S-EPMC12491484 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature