Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish.

ABSTRACT: Gum Arabic (GA) (Acacia senegal var. senegal) is an edible tree exudate and dietary fibre shown to improve health in humans and animals. We tested the ramifications of GAon organismal health across the microbiota-gut-brain axis by supplementing female and male zebrafish (Danio rerio) with two concentrations(6% or 60%) of GA (Acacia senegal var. senegal) for two weeks. We assessed the effects on the gut microbiome composition, intestinal and brain metabolic profiles, reproductive fitness, locomotion, and brain gene expression. GA supplementation induced a relative decrease in Proteobacteria and a relative increase in Fusobacteria, with a rise in the beneficial genus Cetobacterium. In the GA-supplemented fish, we detected increased intestinal glucose metabolism, evidenced by reduced glucose

SUBMITTER: Abi Assaf J 

PROVIDER: S-EPMC12491494 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature