The toxic components, toxicological mechanism and effective antidote for <i>Gelsemium elegans</i> poisoning.

ABSTRACT: Gelsemium elegans (G. elegans) is an extremely poisonous plant that is widely distributed in southern China and southeastern Asia. G. elegans poisoning events occur frequently in southern China, and are therefore an urgent public health problem requiring multidisciplinary action. However, the toxic components and toxicological mechanisms remain unclear. Here, we describe a systematic investigation on the toxic components of G. elegans, resulting in the isolation and identification of 120 alkaloids. Based on acute toxicity screening, the structure-toxicity relationship of Gelsemium alkaloids was proposed for the first time. Moreover, gelsedine- and humantenine-type alkaloids were detected in the clinical blood sample, and were confirmed to be causative in

SUBMITTER: Li N 

PROVIDER: S-EPMC12491680 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature