Transcranial Direct Current Stimulation in Parkinson's Disease Patients in the Off State: A Randomized Controlled Crossover Trial Examining the Effects on Pain With and Without the Influence of Dopaminergic Medication.

ABSTRACT:

Background

tDCS has demonstrated hypoalgesic effects on Parkinson's disease (PD)-related pain applied in the On state but not in the Off state. We aimed to determine the effect of tDCS in the Off state followed by dopaminergic medication on PD-related pain.

Methods

This randomized controlled crossover trial included 15 patients (age range 39-81, 5 male) with PD-related pain in the Off state. All participants received both an active and sham tDCS sessions of 20 min over the M1 contralateral to pain at 2 mA intensity in two separate days while in Off state. Following tDCS they took its dopaminergic medication. Outcome measures were assessed at baseline, post-tDCS and post-medication intake. The Numeric Pain Rating Scale (NPRS), Global Rating Of Change (GROC), Conditioned Pain

SUBMITTER: Gonzalez-Zamorano Y 

PROVIDER: S-EPMC12491758 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature