Preoperative network activity predicts the response to subthalamic DBS for Parkinson's disease.

ABSTRACT: Quantitative imaging markers to aid in the selection of Parkinson's disease (PD) patients for surgical interventions such as subthalamic nucleus deep brain stimulation (STN-DBS) are currently lacking. Using metabolic PET and network analysis we identified and validated a treatment-induced topography, termed STN StimNet. Stimulation-mediated changes in network expression correlated with concurrent motor improvement in independent STN-DBS cohorts scanned on and off stimulation. Moreover, STN StimNet measurements off stimulation correlated with local field potentials recorded from the STN, whereas intraoperative modulation of cortical activity by STN stimulation correlated with contributions to the network from corresponding brain regions. These findings suggested that stimulation-mediated cl

SUBMITTER: Unadkat P 

PROVIDER: S-EPMC12491795 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature