Deep brain stimulation improves symptoms across all dimensions in treatment-resistant depression.

ABSTRACT: Deep brain stimulation (DBS) reduces depressive symptom scores in many patients with treatment-resistant depression (TRD). However, it is unclear whether the observed improvement is similar across various symptom dimensions (e.g., anhedonia, anxiety, insomnia) or if some require additional clinical attention. Using a retrospective chart review, we assessed the trajectory of HAM-D-17 and MADRS scores during vALIC or slMFB DBS treatment within different symptom dimensions (HAM-D-17: 1) affective/anhedonia, 2) somatic/anxiety, 3) insomnia; MADRS: 1) affective/anhedonia, 2) anxiety/vegetative, 3) hopelessness) after at least a 25 ​% symptom reduction (partial response) at any time during their treatment course (n ​= ​34 for HAM-D-17, n ​= ​25 for MADRS). Results showed that each of the assesse

SUBMITTER: Runia N 

PROVIDER: S-EPMC12491800 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature