Temporal trends in treatment-related cardiopulmonary disease-specific mortality in NSCLC based on pathological subtypes: a retrospective population-based cohort study.

ABSTRACT:

Background

While cancer-specific mortality has decreased with therapeutic advances, a growing proportion of survivors are at risk of treatment-related adverse effects (AEs).

Objectives

To assess cardiopulmonary disease-specific mortality risks in patients with non-small-cell lung cancer (NSCLC) based on pathological subtypes.

Design

This was a retrospective cohort study. Mortality data from the Surveillance, Epidemiology, and End Results Program database and AE data from the FDA Adverse Event Reporting System were analyzed in NSCLC patients. In addition, an independent validation cohort comprising 161 NSCLC patients was enrolled.

Methods

The piecewise regression was established using the Joinpoint software to characterize temporal trends. Univariate and multiva

SUBMITTER: Mo Y 

PROVIDER: S-EPMC12491816 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature