Accelerated biological aging as potential mediator in the relationship between central obesity and lung cancer risk.

ABSTRACT:

Background

The increased prevalence of obesity and incidence of lung cancer have raised significant concerns worldwide. However, the relationship between obesity and lung cancer risk, and the potential mediating effect of biological aging remains poorly understood.

Methods

Using UK Biobank database, this population-based cohort study employed multivariable Cox regression to estimate HRs (Hazard Ratios) for obesity indices (waist circumference [WC], waist-hip ratio [WHR], body shape index [ABSI], conicity index [C-Index]) and lung cancer risk. Biological aging was evaluated via PhenoAge and Klemera-Doubal method age (KDMAge), with acceleration calculated by regressing biological on chronological age. Longitudinal mediation analysis explored their mediating effects.

Results

SUBMITTER: Liu H 

PROVIDER: S-EPMC12491821 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature