Extracellular vesicles from prostate tumors reshape the pre-metastatic bone environment in an mTOR/RAB1A-dependent manner.

ABSTRACT:

Background

Bone is the most common metastatic site in prostate cancer (PCa) patients and serves as a key contributing factor to the poor prognosis observed in advanced-stage patients. Mammalian target of rapamycin (mTOR) inhibition has limited clinical efficacy, potentially due to pathway complexity. Prior to the colonization by tumor cells, primary PCa cells actively remodel the bone microenvironment through the secretion of mediators including extracellular vesicles (EVs). The objective of this research is to investigate the regulatory mechanisms of EV biogenesis and the effects of EVs on the bone pre-metastatic niche (PMN), offering a novel therapeutic strategy against bone metastasis.

Methods

PCa cell lines were employed to detect mTOR and Ras-related protein Rab-1A (RAB

SUBMITTER: Lv T 

PROVIDER: S-EPMC12491827 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature