Five-repetition chair-stand test vs. handgrip strength: Which better predicts mortality risk? a follow-up study in 43,605 middle-aged and older adults.

ABSTRACT:

Background

Ageing reduces muscle strength and function, increasing mortality risk. Identifying simple performance markers can guide interventions for healthy ageing.

Objective

To assess the prospective dose-response association of the 5-repetition Chair Stand Test (5-CST) and handgrip strength (HGS) with mortality in middle-aged and older adults.

Methods

This prospective study included community-dwelling participants aged 50 years or older from the SHARE study. HGS and 5-CST were assessed at baseline, with all-cause mortality tracked through follow-up interviews. Cox regression with restricted cubic splines was used, controlling for several confounders.

Results

43,605 participants (mean age (SD): 65.3 (9.1), 54 % women) were included. During a mean follow-up of

SUBMITTER: Nunez-Cortes R 

PROVIDER: S-EPMC12492024 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature