Active ingredients isolated from <i>Periplaneta americana</i> L. inhibit the inflammation of the colonic mucosa and regulate the gut microbiota in DSS-induced ulcerative colitis in mice.

ABSTRACT:

Introduction

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by colonic mucosal inflammation, compromised intestinal barrier function, and gut microbiota dysbiosis. Current therapies often have significant limitations, including adverse effects, highlighting the need for safer alternatives. Periplaneta americana L. (PA), documented in Shennong's Herbal Classic, possesses anti-inflammatory, tissue-repairing, and immunomodulatory properties. While previous studies demonstrated efficacy of PA in rodent UC models generated using different inducers, the active components within aqueous extracts (PAW) and their comparative effects remain unclear.

Materials

To address this gap, this study investigated the composition and therapeutic activity of

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12492031 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature