Efficacy and Safety of Linaclotide as an Adjunct to Polyethylene Glycol in Bowel Preparation: A Meta-Analysis.

ABSTRACT:

Objectives

Linaclotide, a guanylyl cyclase-C agonist, may enhance efficacy and tolerability when combined with polyethylene glycol (PEG) for bowel preparation. This meta-analysis evaluated linaclotide plus PEG versus PEG alone for bowel preparation prior to colonoscopy.

Methods

Randomized controlled trials (RCTs) including adults undergoing colonoscopy that compared linaclotide plus PEG with PEG alone for bowel preparation were identified via database search up to March 2024. Statistical analysis was performed in RevMan Web using random-effects models.

Results

Eleven RCTs were analyzed. Adequate bowel preparation rate was comparable (risk ratio [RR] 1.01, 95% confidence interval [CI] 0.98-1.04; I² = 23%), as was cecal intubation rate (RR 1.01, 95% CI 1.00-1

SUBMITTER: Shahzil M 

PROVIDER: S-EPMC12492060 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature