Brain network dynamics during rumination relate to relapse of depression.

ABSTRACT:

Background

Rumination is a maladaptive cognitive style and a risk factor for relapse of depression. However, the clinically relevant pattern of dynamic network reconfiguration during rumination in remitted depression and its implication in relapse remained unclear.

Methods

We employed a rumination induction neuroimaging paradigm in which subjects would be guided into an active rumination state and a distraction state. Forty-two patients with remitted depression were involved. Participants underwent assessments of rumination behavior and imaging tasks, and were then monitored for two year to assess the potential relapse of depression. A time-resolved community detection approach was applied to investigate the temporal dynamics of brain networks, and the dynamic network proper

SUBMITTER: Shu S 

PROVIDER: S-EPMC12492253 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature