Mixture effects of prenatal exposure to polybrominated diphenyl ethers on urinary oxidative stress biomarkers in the Chemicals in Our Bodies cohort.

ABSTRACT: Polybrominated diphenyl ether (PBDE) exposure is associated with preterm birth. Laboratory studies suggest that PBDEs lead to elevated oxidative stress, a known contributor to preterm birth, according to epidemiologic studies. We hypothesized that elevated levels of PBDEs would be associated with increased oxidative stress during human pregnancy. Participants in this analysis were enrolled in the Chemicals in Our Bodies cohort and resided in the San Francisco Bay Area (n = 201). Four PBDEs (BDE-47, -99, -100, and -153) were measured in second-trimester serum samples. Urinary oxidative stress biomarkers were measured at 2 time points (second and third trimesters) and included 8-isoprostane-prostaglandin-F2α (8-iso-PGF2α), 2,3-dinor-5,6-dihydro-8-iso-PGF2α, 2,3-dinor-8-iso-PGF2α, and prostag

SUBMITTER: Sehgal N 

PROVIDER: S-EPMC12492299 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature