Perceptions of Daily and On-Demand HIV Pre-Exposure Prophylaxis and Digital Adherence-Support Needs Among Cisgender Men in Brazil: Qualitative Interview and Focus Group Study.

ABSTRACT:

Background

Pre-exposure prophylaxis (PrEP) is a proven effective preventive method in reducing the risk of HIV infection. While daily PrEP is well-established, the on-demand regimen remains less accessible, despite offering advantages, such as a reduced pill burden and lower risk of side effects, particularly for those with variable sexual activity patterns.

Objective

This study explored, from the perspective of PrEP use trajectories, how cisgender men in Brazil choose and adhere to daily or on-demand regimens, and identified key user-informed requirements for designing a digital tool to support on-demand PrEP use.

Methods

A qualitative study was carried out between July 2022 and December 2023 in 5 Brazilian cities. Overall, 19 individual interviews and 5 in-person fo

SUBMITTER: Santos LAD 

PROVIDER: S-EPMC12492313 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature