Amoxicillin or tetracycline in bismuth-containing quadruple therapy for <i>Helicobacter pylori</i> eradication: a systematic review and meta-analysis.

ABSTRACT:

Background

Amoxicillin and tetracycline have been widely used in Helicobacter pylori (H. pylori) eradication therapy, and the priority of their efficacy and safety in Bismuth-containing Quadruple Therapy (BQT) remain controversial.

Materials and methods

A comprehensive systematic review was conducted by searching databases from their inception until June 2025. Studies that compared BQT arms containing amoxicillin with those containing tetracycline were included. Pooled Relative Risks (RR) and 95% Confidence Intervals (CI) of the efficacy and safety outcomes were reported.

Results

Seven randomized controlled trials and two observational studies were included in the meta-analysis. The pooled eradication rates of amoxicillin-containing BQT versus tetracycli

SUBMITTER: Ju K 

PROVIDER: S-EPMC12492358 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature