Ultraviolet-C Treatment Better Preserves the Proteomic Profile of Donor Human Milk than Holder Pasteurization.

ABSTRACT: Consumption of bioactive milk proteins enhances preterm infant development. Preterm infants are often supplemented with donor human milk (DHM) when parents' own milk is unavailable in sufficient quantity. DHM is normally Holder pasteurized (HoP) to inactivate pathogens; however, it denatures many bioactive proteins. Alternatively, ultraviolet-C (UV-C) irradiation can inactivate pathogens while preserving milk proteins. This study examined the effects of HoP and UV-C on the proteome of DHM (n = 1 pool, processing in triplicate). Protein counts in HoP samples (n = 198) were lower than in raw DHM (n = 228) and UV-C at 6000 J/L (n = 239) samples. HoP resulted in significant reductions in relative abundance for 80 proteins (p-values <0.05, >0.5-fold decrease),

SUBMITTER: Kim BJ 

PROVIDER: S-EPMC12492390 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature