Insight into Desorption Mechanisms in a Helium Low-Temperature Plasma Ionization Source Using Computational Simulations.

ABSTRACT: Understanding desorption mechanisms is essential for the optimization of analytical techniques that enable the direct sampling and ionization of condensed-phase samples without preparation. The low-temperature plasma (LTP) ionization source, first described by Harper (Harper; et al. Anal. Chem. 2008, 80, 9097-9104) and based on the dielectric barrier discharge principle, is among the more representative and replicated plasma-based ambient desorption/ionization tools for mass spectrometry (MS), although there are a wide array of designs and configurations. However, the fundamental desorption mechanisms directly associated with LTP and other related plasma-based sources remain unclear. In this study, we utilized plasma simulations using COMSOL Multiphysics to understand analyte releas

SUBMITTER: Gazeli O 

PROVIDER: S-EPMC12492398 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature