An Interventional Radiology Method for In Situ Assessments of Cancer Drug Response: Preclinical Development, Feasibility, and Safety.

ABSTRACT: Purpose To evaluate the technical feasibility and safety of a nonsurgical interventional method for placement and retrieval of implantable microdevices (IMDs) in a rabbit tumor model. Materials and Methods This prospective preclinical feasibility and safety study was conducted from March 2022 to October 2024. Interventional IMD placement and retrieval were performed in 12 rabbits with single hindlimb VX2 tumors. Four or five IMDs were placed per animal. Each IMD delivered microdose quantities of three drugs (doxorubicin, topotecan, sunitinib) into 18 spatially distinct microscopic tumor regions over 24-48 hours. An over-the-wire biopsy procedure was used to extract the IMDs and surrounding tumor. Technical success was defined per animal as retrieval of at least one tumor region containing

SUBMITTER: Bhagavatula SK 

PROVIDER: S-EPMC12492436 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature