Prognostic significance and therapeutic implications of redox metabolism-related genes in head and neck squamous cell carcinoma.

ABSTRACT: Head and neck squamous cell carcinomas (HNSC) are associated with alterations in redox metabolism. This study aims to identify differentially expressed genes (DEGs) related to redox metabolism in HNSC and assess their prognostic values. We utilized the limma package for identifying redox metabolism-related DEGs and performed univariate and multivariate Cox regression analyses to evaluate their prognostic significance. Gene set variation analysis (GSVA), immune cell infiltration analysis, and single-cell RNA sequencing were utilized to explore the relationships between gene expression and tumor processes. Chemotherapy sensitivity was assessed based on ERP44 expression levels. Additionally, pan-cancer analysis was conducted to evaluate ERP44 expression and its prognostic value

SUBMITTER: Yang L 

PROVIDER: S-EPMC12492447 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature