Early Versus Late Diagnosis of Youth-Onset Type 2 Diabetes.

ABSTRACT:

Objective

To determine if earlier age of diabetes onset (< 15 years of age) is associated with a worse metabolic phenotype compared to diabetes diagnosed at a later age (≥ 15 years of age).

Methods

Retrospective cross-sectional study of our clinical cohort was performed at a tertiary clinic between 2018 and 2023. Diabetes presentation (diabetic ketoacidosis, C-peptide levels, ketonuria), metabolic phenotype (body mass index (BMI) z-score, hypertension, dyslipidemia, elevated liver enzymes, and haemoglobin A1c) were compared between youth diagnosed with type 2 diabetes who were < 15 years of age and those ≥ 15 years of age. A p value of < 0.05 was considered significant.

Results

We studied n = 336 youth. Mean age was 14.5 years at type 2 diabetes diagnosis, n = 198 wer

SUBMITTER: Krishnan N 

PROVIDER: S-EPMC12492476 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature