CX₃CR1 fate mapping <i>in vivo</i> distinguishes cochlear resident and recruited macrophages after acoustic trauma.

ABSTRACT:

Introduction

Cochlear injury activates the resident macrophages (RM) and recruits the blood-circulating monocytes and monocyte-derived macrophages (Mo/Mo-M), but their specific functions in the injured cochlea are unknown. It is well-established that the chemokine fractalkine receptor (CX₃CR1), expressed by cochlear macrophages, influences the density of those macrophages and promotes synaptic repair and spiral ganglion neuron (SGN) survival in the injured cochlea. As CX₃CR1 is expressed on both RM and Mo/Mo-M, it remains unclear if CX₃CR1- expressing RM and Mo/Mo-M are distinct and differentially promote SGN survival after cochlear injury.

Methods

We used a fate mapping tamoxifen-inducible CX₃CR1 mouse model (CX₃CR1

SUBMITTER: Murali SV 

PROVIDER: S-EPMC12492497 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature