Phase-separating fusion proteins drive cancer by upsetting transcription regulation.

ABSTRACT:

Background

Numerous cellular processes rely on biomolecular condensates formed through liquid-liquid phase separation (LLPS). Recently, it has become evident that somatic mutations can interfere with or over-activate the formation of phase-separated condensates.

Results

Here, we set out to systematically study the connection between cancer and biological condensation, specifically mapping the extent to which LLPS is affected in cancer and understanding the molecular pathomechanisms and therapeutic consequences of mutations affecting LLPS scaffolds. We identify both known and novel combinations of molecular functions that are specific to oncogenic fusion proteins and thus have a high potential for driving tumorigenesis. Protein regions driving condensate formation show an inc

SUBMITTER: Farahi N 

PROVIDER: S-EPMC12492527 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature