Aging-related signature stratifies LUAD prognosis and uncovers senescence-induced chemoresistance via NF-κB/RELA activation.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer and a leading cause of cancer-related mortality worldwide. Aging has emerged as a significant risk factor for LUAD, with evidence suggesting that age-associated biological changes may influence prognosis. However, the underlying molecular mechanisms linking aging to tumor progression and therapy resistance are not fully understood.

Methods

We integrated transcriptomic data from LUAD cohorts to identify aging-related genes that are differentially expressed and associated with prognosis. Then Cox regression was utilized to establish an aging-related signature. Patients were stratified based on the signature, and we examined survival differences and transcription factor expression between groups. In

SUBMITTER: Zhu C 

PROVIDER: S-EPMC12492542 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature