MiR-125b-5p and miR-145a-5p modulation drives functional enhancement of Wharton's Jelly-MSCs derived small extracellular vesicles in response to hypoxia preconditioning.

ABSTRACT:

Background

Regenerative medicine therapies offer hope for conditions previously limited to supportive care. The COVID-19 pandemic underscored the urgent need for treatments targeting systemic inflammation. Mesenchymal stem cells (MSCs) are widely recognized for their regenerative and immunomodulatory properties. Recent research shows that hypoxic priming enhances MSCs' therapeutic potential, particularly by increasing the release and modifying the cargo of their extracellular vesicles (EVs). These EVs imitate many of the regenerative and immunomodulatory effects of MSCs, making them a promising cell-free therapeutic option. This study aimed to compare the regenerative and immunomodulatory capacities of small EVs (sEV; less than 200 nm) derived from bone marrow (BM) and wharton's je

SUBMITTER: Sharma Y 

PROVIDER: S-EPMC12492563 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature