Risk factors for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation: a systematic review and meta-analysis.

ABSTRACT:

Background

Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a late-onset complication that significantly impairs patients' quality of life and is associated with a high mortality rate. Currently, the risk factors for BOS after HSCT remain controversial. We therefore conducted a systematic review and meta-analysis to identify potential risk factors associated with BOS after HSCT.

Methods

Three primary medical databases (PubMed, Web of Science, Embase) were exhaustively reviewed from their inception through November 2024 to assess contributing factors for BOS occurrence following HSCT. Data synthesis was conducted using RevMan 5.4 for meta-analytic evaluation.

Results

Fourteen studies involving 10,317 HSCT recipients were i

SUBMITTER: Pu G 

PROVIDER: S-EPMC12492564 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature