The effects of vasopressor choice on renal outcomes in septic shock: a systematic review of randomised trials as a guide for future research.

ABSTRACT:

Background

Patients with septic shock are high risk for developing acute kidney injury (AKI), with its associated morbidity. This systematic review assessed the evidence for an effect on renal outcomes from choice of vasopressor.

Methods

Searches were conducted on Medline, Embase, Cochrane Central, congress abstracts and trial registries. The search strategy included septic shock, vasopressor agents and renal impairment. Inclusion criteria were non-crossover randomised controlled trials of adult septic shock comparing individual or combinations of vasopressors and placebo controlled trials. Primary outcome was the incidence of AKI in study participants. Secondary outcomes were AKI duration, renal replacement therapy (RRT) rate, RRT duration, renal failure free days, requirem

SUBMITTER: McDonald R 

PROVIDER: S-EPMC12492594 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature