Black-spot linked gut microbiota shifts in Oujiang color carp: insights from TYR knockout and metabolomic integration.

ABSTRACT:

Background

Growing insights into gut microbiota reveal their surprising role in shaping external traits in fish, including the regulation of skin pigmentation. This study explores whether black-spot pigmentation influences the abundance of gut microbiota. We investigate how black-spot pigmentation in Oujiang color common carp shapes gut microbiome composition, gene expression, and metabolite, revealing a coordinated gut-skin color axis. To validate these findings, we used a TYR knockout group, which included both mutant black-spotted (TYR ^+/-) and non black-spotted (TYR ^-/-) fish, enabling functional comparison across pigmentation phenotypes.

Results

We demonstrate that black-spotted (RB and WB) fish groups contained less total microbiome composition am

SUBMITTER: Kanika NH 

PROVIDER: S-EPMC12492632 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature