Emergence, surge, and fading of the novel feline parvovirus Thr390Ala mutant in Egyptian cats during 2023: insights from a comprehensive full-length VP2 genetic analysis.

ABSTRACT:

Background

Feline parvovirus (FPV) causes feline panleukopenia (FPL) and cerebellar ataxia (CA) in cats. to date, only two complete Egyptian VP2 sequences have been available in GenBank. To investigate FPV diversity And evolution in Egypt, we generated 24 complete VP2 sequences from diseased cats during two FPV activity peaks in 2023 (January-February and November-December). Egyptian sequences were Analyzed with 967 global references to assess selection pressure and phylogenetic relationships. In silico predictions of VP2 Antigenic sites, 3D structure, and phosphorylation potential were performed to evaluate the impact of identified mutations.

Results

Egyptian sequences showed 99.3-100% nt And 99.8-100% aa identity among themselves, And 98.6-100% nt And 98.4-100% aa identity

SUBMITTER: Safwat MS 

PROVIDER: S-EPMC12492670 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature