Revealing the potential value of urine microbiota in ureteral stent encrustation after renal transplantation via Illumina sequencing of 16S rRNA genes.

ABSTRACT:

Background

The complication of ureteral stent encrustation (USE) has brought many challenges and troubles to clinical treatment after renal transplantation. The aim of this study was to explore the microbiota that may be involved in the formation and progression of encrustation in ureteral stents.

Methods

In total, 15 patients with ureteral stent non-encrustation (USNE) after renal transplantation and 18 patients with USE after renal transplantation were included in this study. The urine microbiota was analyzed by 16 S rRNA gene sequencing, followed by composition analysis, difference analysis and PICRUSt function prediction. In addition, random forest classification diagnostic models were constructed based on urine microbiota.

Results

Compared to the USNE-U group, th

SUBMITTER: Chen J 

PROVIDER: S-EPMC12492672 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature