Newly isolated bacteriophages show efficacy and phage-antibiotic synergy in vitro against the equine genital pathogens Klebsiella pneumoniae and Pseudomonas aeruginosa.

ABSTRACT:

Background

Bacterial infections of the genital tract are a severe problem in equine reproduction. Biofilms produced by Klebsiella (K.) pneumoniae and Pseudomonas (P.) aeruginosa present further concerns in such cases as they can limit the success of antibiotic treatments. Alternative treatment approaches are urgently needed for treating bacterial equine genital tract infections and thus, reduce antibiotic use. The present study reports on the bactericidal efficacy of both, novel K. pneumoniae- and P. aeruginosa-specific phages, in a biofilm model and in conjunction with antibiotic drugs as tested in vitro.

Results

In total, 15 phages with lytic activity (K. pneumoniae: n = 6; P. aeruginosa: n = 9) were isolated and host ranges were determined. Four phages with a broad host r

SUBMITTER: Kohne M 

PROVIDER: S-EPMC12492686 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature