Unraveling the pathogenic potential, virulence traits, and antibiotic resistance genes of multidrug-resistant Streptococcus agalactiae strains retrieved from Nile tilapia.

ABSTRACT:

Background

Streptococcus agalactiae is implicated in severe infections in humans and causes considerable financial losses in the aquaculture industry, particularly in tilapia farming. Given its dual threat to public health and food security, this study was conducted to comprehensively assess the prevalence, molecular identification, multidrug resistance (MDR) patterns, virulence traits, antimicrobial resistance genes, and pathogenic potential of S. agalactiae strains isolated from Oreochromis niloticus. Notably, this study highlights the detection of critical virulence genes (cfb, hylB, lmb, and cylE), which play essential roles in host invasion and immune evasion. In parallel, the presence of resistance determinants such as pbp1A, aac(6')-aph(2''), tetM or tetK, and ermB or ermA u

SUBMITTER: Algammal AM 

PROVIDER: S-EPMC12492693 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature