Preventing volume loss during extubation in preterm infants: a prospective observational study.

ABSTRACT:

Background

To evaluate changes in end-expiratory lung impedance (EELI), a surrogate for end-expiratory lung volume (EELV), during a minimal-handling extubation protocol in very preterm infants in prone position. The protocol aimed to minimize interruptions in positive end-expiratory pressure (PEEP) delivery.

Methods

This was a prospective observational study including preterm infants born before 32 weeks' gestation who underwent elective extubation without conditions negatively impacting lung aeration or perfusion. Participants were recruited at the University Hospital Zurich (June 2023-March 2024). We compared a novel extubation protocol that minimizes infant handling to a conventional protocol. Lung volume changes were continuously monitored noninvasively via electrical im

SUBMITTER: Plastina L 

PROVIDER: S-EPMC12492717 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature