Surveillance and characterization of carbapenem-resistant Enterobacter cloacae complex from China, 2015-2018.

ABSTRACT:

Background

The carbapenem-resistant Enterobacter cloacae (CREC) have become a global health concern. However, our understanding of its epidemiological trends and resistance mechanisms still needs to be improved.

Methods

Ninety-one non-repetitive clinical CREC isolates were collected from 12 hospitals across China and identified using MALDI-TOF MS, rMLST, ANI, MASH, and dDDH. Minimal inhibitory concentrations were determined via broth microdilution. Resistance genes and plasmid replicons were identified using ResFinder and PlasmidFinder. Carbonyl cyanide 3-chlorophenylhydrazone suppression test and OmpC and OmpF overexpression test were conducted on 32 non-carbapenemase-producing (NCP) isolates. A phylogenetic tree was constructed with kSNP4 and visualized through iTOL.

Re

SUBMITTER: Ye K 

PROVIDER: S-EPMC12492719 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature