Diffusion tensor imaging analysis of aged dogs with and without canine cognitive dysfunction.

ABSTRACT:

Background

Canine cognitive dysfunction (CCD) is a naturally occurring disease in aged dogs that shares behavioral and pathological similarities with Alzheimer's disease (AD). Despite this, in vivo imaging of CCD has been limited, and to our knowledge, no studies have investigated the use of diffusion tensor imaging (DTI) to assess brain atrophy in this condition. The primary aim of this study was to determine whether DTI could detect differences in white matter microstructure between aged dogs with CCD and cognitively healthy aged dogs. A secondary aim was to evaluate correlations between DTI parameters and cognitive scores derived from the Canine Dementia Scale (CADES). We hypothesized that dogs with CCD would show lower fractional anisotropy (FA) and higher mean diffusivity (MD)

SUBMITTER: Henry J 

PROVIDER: S-EPMC12492749 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature