Salivary mycobiome diversity at different stages of human immunodeficiency virus infection.

ABSTRACT:

Background

The oral cavity is a common site for fungal infections in people living with HIV/AIDS (PLWHA), yet reports on oral mycobiome alterations remain limited. This study aimed to analyze differences in mycobiome diversity and community composition in the saliva of PLWHA at different infection stages.

Methods

Non-stimulated whole saliva samples were collected from 63 HIV-infected/AIDS patients, who were divided into four groups based on the CDC staging criteria (stage 0, n = 10; stage 1, n = 13; stage 2, n = 24; stage 3, n = 16), as well as from 24 HIV-negative individuals. Internal Transcribed Spacer (ITS) sequencing was employed to analyze species diversity and community composition differences, and correlations at the genus level with CD4⁺ T cell counts and HIV blood

SUBMITTER: Lin L 

PROVIDER: S-EPMC12492769 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature