The association between heart rate variability and inflammatory markers in first-episode depressed patients with different sleep quality.

ABSTRACT:

Objective

To investigate the associations between systemic inflammatory markers and heart rate variability (HRV) parameters across different levels of sleep disturbance in patients with first-episode depression.

Methods

A total of 76 patients with first-episode moderate-to-severe depression and 30 healthy controls were enrolled. Patients were stratified into three groups based on Pittsburgh Sleep Quality Index (PSQI) scores: low (LSD), moderate (MSD), and severe (SSD) sleep disturbance. Peripheral inflammatory markers and 24-hour HRV parameters were measured. Partial Spearman correlation analyses were performed adjusting for age, sex, BMI, smoking status, and alcohol consumption.

Results

Significant group differences were observed in inflammatory markers (IL-6, IL-1β,

SUBMITTER: Alimu A 

PROVIDER: S-EPMC12492808 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature