The effects of norepinephrine in shockable cardiac arrest, a scoping review.

ABSTRACT:

Background

Out-of-hospital cardiac arrest is considered a major public health issue with an incidence of 67-170 per 100.000 inhabitants in Europe. Sufficient coronary perfusion pressure is a requisite for successful defibrillation and return of spontaneous circulation (ROSC). Although epinephrine (E) was found to increase ROSC and hospital survival when compared to placebo, its role in shockable arrest is under debate due to the absence of favorable neurological outcome.

Objective

Norepinephrine (NE) increases coronary perfusion pressure and may be an alternative for epinephrine because of differences in affinity in alpha- and beta- adrenergic receptors.

Methods

An extensive literature search was conducted in PreMedline, Medline, Embase and Cochrane electronic databas

SUBMITTER: Bouman SJM 

PROVIDER: S-EPMC12492856 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature