BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer.

ABSTRACT:

Background

BRD9 is involved in multiple physiological and pathological pathways, yet its functional role and molecular mechanisms in gastric cancer (GC) remain largely unexplored. Addressing this knowledge gap is critical given the persistent global mortality burden of GC and the limited efficacy of current therapeutic strategies.

Methods

BRD9 expression in GC patients was systematically analyzed using immunohistochemical (IHC) assays and transcriptomic datasets. Comprehensive functional validation, employing cellular and murine tumor models, elucidated BRD9's role in GC progression. Molecular pathways underlying BRD9-mediated gastric carcinogenesis were delineated through integrated approaches, including RNA sequencing, co-immunoprecipitation (co-IP), subcellular fractionat

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC12492862 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature