Automated larval motility assays reveal links between eprinomectin treatment failure and drug resistance in Haemonchus contortus.

ABSTRACT: Small ruminants are frequently infected with gastrointestinal nematode parasites (GIN) such as the highly pathogenic Haemonchus contortus, which severely impact animal health, welfare and production performance. The increasing prevalence of clinical anthelmintic resistance poses a global threat to effective parasite control and the productivity of livestock farming. This includes resistance to eprinomectin (EPR), the only anthelmintic currently approved for use in dairy production with a zero-withdrawal period. This study aims to link EPR therapeutic failure against H. contortus in dairy sheep farms in southwestern France with drug potency, as determined via the larval motility phenotype in an in vitro test. Six field isolates (four EPR-resistant and two EPR-susceptible isolates) were coll

SUBMITTER: Petermann J 

PROVIDER: S-EPMC12492879 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature