FOXK1 regulates apoptosis, migration and angiogenesis in high glucose-induced vascular endothelial cells through p-AKT/AKT signaling pathway.

ABSTRACT:

Background

Forkhead box K1 (FOXK1) is a newly discovered gene encoding a transcription factor in the FOX family. It plays important roles in the cell cycle, cell growth, proliferation, differentiation, apoptosis, metabolism, DNA damage, drug resistance, angiogenesis, and carcinogenesis by binding to DNA to function as a transcription factor. Many studies have confirmed that FOXK1 plays a role in promoting cancer in a variety of tumors. However, the pathogenic role of FOXK1 in diabetic retinopathy (DR) is still unclear. The present study was conducted to investigate the mechanism of FOXK1 in the vascular endothelial dysfunction of DR.

Methods

Human umbilical vein endothelial cells (HUVECs) were exposed to high glucose (HG) concentrations (25 mmol/L) to establish a vascular en

SUBMITTER: Long H 

PROVIDER: S-EPMC12492899 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature