Spatiotemporal analysis of dystrophin expression during muscle repair.

ABSTRACT:

Background

Dystrophin mRNA is produced from a very large genetic locus and transcription of a single mRNA requires approximately 16 h. This prolonged interval between initiation and completion results in unusual transcriptional behaviour: in skeletal muscle, myonuclei express dystrophin continuously and robustly, yet degrade mature transcripts shortly after completion. Consequently, most dystrophin mRNA is nascent, not mature. This implies expression is principally controlled post-transcriptionally, a mechanism that circumvents transcriptional delay, allowing rapid responses to change in demand. Dystrophin protein is however highly stable, with slow turnover: in healthy muscle, despite constant production of dystrophin mRNA, demand is low and the need for responsive expression is m

SUBMITTER: Hildyard JCW 

PROVIDER: S-EPMC12492914 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature