Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency.

ABSTRACT:

Background

Epigenetic modifications, nucleosome occupancy, and three-dimensional chromatin architecture collectively create a multi-layered, highly interactive regulatory system for controlling genomic functionality. Dysregulation of epigenetic processes leads to a plethora of abnormalities including disease states. Therapies focused on epigenetic modulation can alter gene expression to correct dysfunction, though the perpetuation of these states and the relationships among chromatin regulatory layers is not well understood.

Results

Here, we investigated global and local chromatin structural and functional responses after acute histone deacetylase inhibitor treatment (suberoylanilide hydroxamic acid) in lung cancer cells across time. Treatment substantially increased global

SUBMITTER: Venu V 

PROVIDER: S-EPMC12492967 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature