Use of new CORE risk score to predict 10 year risk of liver cirrhosis in general population: population based cohort study.

ABSTRACT:

Objective

To develop and validate a novel risk prediction model for incident major adverse liver outcomes (MALO) in a primary care setting.

Design

Population based cohort study.

Setting

Sweden, with validation in Finland and the UK.

Participants

Model development in 480 651 individuals with no known history of liver disease and blood tests taken in primary care or at occupational healthcare screenings; validation in two cohorts with 24 191 and 449 806 individuals without known history of liver disease.

Main outcome measures

10 year risk of a composite outcome of compensated and decompensated cirrhosis, hepatocellular carcinoma, liver transplant, and liver related mortality, collectively referred to as MALO.

Results

A new risk model was created usi

SUBMITTER: Strandberg R 

PROVIDER: S-EPMC12492969 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature