Risk prediction models for cancer therapy related cardiac dysfunction in patients with cancer and cancer survivors: systematic review and meta-analysis.

ABSTRACT:

Objectives

To systematically review all prediction models developed or validated for cancer therapy related cardiac dysfunction (CTRCD) and to quantitatively analyse their performance.

Design

Systematic review and meta-analysis.

Data sources

Embase, Medline, and the Cochrane Central Register of Controlled Trials, from inception to 23 August 2024.

Eligibility criteria for selecting studies

Studies that developed or externally validated multivariable models to predict CTRCD risk in young people (children, adolescents, and young adults (≤39 years)) or older adults (≥40 years) with cancer or cancer survivors treated with systemic antineoplastic agents. Studies on radiation induced cardiotoxicity were excluded.

Methods

Two reviewers independently screened stu

SUBMITTER: Gomes C 

PROVIDER: S-EPMC12492976 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature