Effect of 4-Position Pyridine Ring Substitution on Zn(II) Complexes of 4-substituted Py₂N₂ Pyridinophane Macrocycles.

ABSTRACT: The metal binding properties of macrocyclic small molecules is a key property that drives what applications for which these ligands can be used. Pyridine modified Py₂N₂ pyridinophane small molecules are a new class of macrocyclic small molecules, whose properties have not been explored. As a result, Zn(II) metal binding of a library of six pyridine modified Py₂N₂ complexes are reported here. These results include ¹H NMR, log β_Zn(II), and X-ray diffraction, which are compared to PyN₃ congeners to show that the differences in each scaffold yield markedly different metal binding properties that can be exploited in future applications.

SUBMITTER: Smith KJ 

PROVIDER: S-EPMC12492988 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature