Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome.

ABSTRACT: Brain regions in Alzheimer's disease exhibit distinct vulnerability to its hallmark pathology with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like the primary sensory cortices remain resilient. The quest to understand how local/regional genetic factors, pathogenesis and network-mediated pathology spread, together govern this selective vulnerability (SV) or resilience (SR) is ongoing. Although many Alzheimer's risk genes are known from gene association and transgenic studies, it is still unclear whether and how their baseline expression confers SV/SR to pathology. Prior analyses have yielded conflicting results, pointing to a disconnect between the location of genetic risk factors and downstream tau pathology. The spatial distribution of vulnerability

SUBMITTER: Anand C 

PROVIDER: S-EPMC12493037 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature